By William W. Cohen
This ebook is designed in particular as a advisor for computing device Scientists desiring an creation to mobile Biology. The textual content explores 3 diverse features of biology: organic structures, experimental tools, and language and nomenclature. the writer discusses what biologists try to figure out from their experiments, how quite a few experimental tactics are used and the way they relate to authorised strategies in machine technology, and the vocabulary essential to learn and comprehend present literature in biology. The e-book is a useful reference instrument and a very good start line for a extra accomplished exam of telephone biology.
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Extra info for A Computer Scientist's Guide to Cell Biology
Consider a Western blot, which tests a protein X for interactions with the proteins on a blot: the experiment remains the same, whether the blot contains 100 proteins, 1000 proteins, or 10,000 proteins. If you like, the 2D gel functions as a 2D array of tiny little columns, just like those used in affinity chromatography— columns which can be easily used in parallel. More intriguingly, it is as easy to test a mixture of 1000 proteins X1, …, X1000 against this “array of columns” as it is to test a single protein X!
In single-celled organisms, a proteomic difference might be due to a response to different William W. Cohen 51 environments—for instance, different nutrients, or different temperatures. In a multi-celled organism, cells from different tissues express different sets of proteins. Studying such differences in genetic expression is a frequent goal in experimental biology. Since proteins are always encoded by mRNA before they are built, one (indirect) way to detect differences in the proteomes of two cells is to compare their sets of mRNAs.
Both of these procedures (to put it moderately) tend to cause damage, so preserving a specimen in something like its native state is often a major challenge for electron microscopy. Work on using electron microscopes in close-to-normal conditions is an active area of research, however. William W. Cohen E 43 F Electron microscope images. (A) human HeLa cells (B) the inset in (A), further magnified. (C) hamster CHO cells, with some mitochondria shown in the inset. (D) actin filiments. (E) part of the intestinal cell of a 4-day old rat.
A Computer Scientist's Guide to Cell Biology by William W. Cohen